Tus nqi tshuaj ntawm txiv laum huab xeeb

① Hemostatic nyhuv
Nws tau pib pom tias cov txiv laum huab xeeb hauv qhov ncauj tuaj yeem txo cov tsos mob los ntshav hauv cov neeg mob hemophilia, tab sis tom qab ntawd nws tau paub tias nws tsis yog tsuas yog siv tau rau cov neeg mob hemophilia hom A (ua los ntawm qhov tsis zoo Ⅷ), tab sis kuj zoo dua rau cov neeg mob hemophilia hom. B (tsis muaj qhov tseem ceeb IX), thiab nws kuj muaj cov nyhuv hemostatic rau qee cov neeg mob los ntshav, tab sis rau cov neeg mob los ntshav hnyav, nws cov nyhuv tsis zoo heev. Cov nyhuv ntawm txiv laum huab xeeb yog 50 npaug zog dua li txiv laum huab xeeb nws tus kheej, thiab cov nyhuv txo qis heev tom qab kib (20 zaug tsis muaj zog). Ib hnub koob tshuaj 10 grams ntawm daim tawv nqaij extract yog zoo. Nws yog thawj zaug hais tias hexane yuav tsum tau siv rau extraction, tab sis tam sim no ethanol yog siv rau extraction, uas yog, 200 grams ntawm txiv laum huab xeeb nplej yog do-kib, 2 kg ntawm 96 feem pua ​​​​ethanol yog tsau rau 96 teev, thiab 8 teev ib hnub twg. yog nquag nplawm, sawv, lim, evaporating filtrate, residue yog diluted rau 100 grams nrog 96 feem pua ​​​​ethanol, 40 tee yog noj ntawm qhov ncauj 4 zaug ib hnub twg. Lub hauv paus ntsiab lus ntawm nws cov nyhuv hemostatic tsis tau qhia meej meej, thiab nws tsis muaj kev cuam tshuam tshwj xeeb rau hemophilia cov ntshav coagulation tsis zoo, tsuas yog txo cov tsos mob los ntshav, thiab tsis nce cov ntsiab lus ntawm yam II-X hauv cov ntshav ntawm cov neeg mob. Cov roj txiv laum huab xeeb tsis nce cov ntsiab lus ntawm cov ntsiab lus Ⅱ, Ⅶ thiab Ⅹ hauv cov nas noj cov zaub mov muaj roj ntau, thiab tsis muaj kev cuam tshuam rau tib neeg fibrinogen thiab yam Ⅷ. Peanut daim tawv nqaij tuaj yeem txo lub sijhawm coagulation ntawm cov neeg mob hemophilia mus rau qhov qub. Nws tau raug pom zoo tias nws cov hemostasis cuam tshuam nrog vasoconstriction, tab sis nws tsis tau muaj pov thawj. Nws ntseeg tau tias nws cov hemostasis cuam tshuam nrog kev tiv thaiv fibrinolysis. Kev ua haujlwm fibrinolytic ntawm tib neeg ib txwm tuaj yeem raug txo los ntawm kev tswj hwm qhov ncauj ntawm txiv laum huab xeeb tev (los ntawm 100 feem pua ​​​​mus rau 40 feem pua). Cov txiv laum huab xeeb kuj tseem muaj txiaj ntsig zoo ib yam rau cov luav tau noj zaub mov ib txwm muaj thiab cov roj cholesterol siab. Cov nyhuv no yog vim nws qhov kev ua haujlwm ntawm fibrinolytic enzyme inhibitors, los yog vim nws qhov kev txiav txim ntawm cov proteinolytic enzymes.
Lub semi-refined trypsin inhibitor cais los ntawm txiv laum huab xeeb tuaj yeem ncua sijhawm fibrinolysis, thiab nws cov haujlwm ntau dua li cov taum pauv trypsin inhibitor. Lub sijhawm "euglobulin clot lysis" kuj tseem ntev dua hauv hemophilacs. Nws tau raug pom tias qhov kev kho mob ntawm cov txiv laum huab xeeb ntawm hemophilia yog cuam tshuam nrog cov cholinolipids nws muaj. Tsis tas li ntawd, nws tau raug tshaj tawm tias nws cov extract tuaj yeem txo "lub sijhawm rov ua kom rov ua kom rov qab tau" hauv cov neeg mob hemophiliac, ua kom lub zog ntawm cov ntshav thromboplastin, thiab txhim kho thrombin elasticity. Cov koob tshuaj loj ntawm trypsin inhibitors muaj nyob rau hauv nws tuaj yeem ncua sijhawm thrombin ntau lawm, thiab cov koob tshuaj loj dua tuaj yeem ncua me ntsis ntawm "cov ntaub so ntswg thromboplastin lub sijhawm", tab sis tsis cuam tshuam rau "thrombin lub sijhawm". Nws kuj tau raug pov thawj hauv cov tsiaj txhu tias kev txhaj tshuaj txiv laum huab xeeb rau hauv cov dev ib txwm muaj (10 feem pua ​​​​2 ml / kg) tuaj yeem txo lub sijhawm coagulation, lub sijhawm rov qab calcification, txhim kho cov ntshav siab rau heparin, txhawb thrombosis thiab thrombin kev ua haujlwm; Yog tias qhov kev ua haujlwm fibrinolytic yog qhov cuam tshuam loj heev lossis txo qis ntawm fibrinogen concentration, nws tuaj yeem nce cov ntshav cov ntsiab lus ntawm Factor IX thiab Factor VIII. Hauv kev sim vitro, nws tsis muaj kev cuam tshuam rau kev ua kom cov ntshav txhaws. Nws tau raug tshaj tawm nyob rau xyoo thaum ntxov tias cov extract ntawm txiv laum huab xeeb, uas tshem tawm cov rog thiab cov protein ntau, muaj cov nyhuv zoo li heparin thiab tuaj yeem tiv thaiv cov ntshav txhaws.
② Lwm cov teebmeem Cov noob muaj qee cov nroj tsuag hemagglutinin, uas tuaj yeem ua rau tib neeg cov qe ntshav liab kho nrog sialacidase, thiab muaj cov tshuaj tiv thaiv P agglutinin. Flavus toxin tau yooj yim tsim hauv txiv laum huab xeeb, uas tuaj yeem ua rau mob qog noj ntshav. Lub endothelium ntawm txiv laum huab xeeb muaj cov tshuaj tiv thaiv-fibrinolytic enzyme, uas tuaj yeem tiv thaiv txhua yam kev mob los ntshav, lub siab los ntshav, hemophilia thiab lwm yam. Txawm li cas los xij, txiv laum huab xeeb yog ib qho yooj yim los ua ntub dej thiab pwm, thiab tsim aflatoxin uas yog carcinogenic heev. Aflatoxin tuaj yeem ua rau muaj kab mob siab, mob siab thiab mob qog noj ntshav. Cov tshuaj lom no tiv taus qhov kub thiab txias, thiab kev ua noj xws li kib, kib, boiling, thiab kib tsis tuaj yeem tawg. Yog li peb yuav tsum xyuam xim tsis txhob noj cov txiv laum huab xeeb.